Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM121053
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
11.6±n/a nM
Comments
extracted
Citation
 Zhou, Q; Li, J; Huang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 1
Synonyms:
Prokineticin receptor 1 (PRK1)
Type:
Enzyme
Mol. Mass.:
44908.29
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3HIE5
Residue:
399
Sequence:
MPPPAWMEPTVGALGENTTDTSTSFLSLVNARGAQAASFPFTLSYGDYDTALGEEEDVTKSWTFFAARIVIGMALVAIMLVCGVGNFIFITTLARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQVYYRSYFLLVFGLEFVGPVVAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVSVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGMPATEEVDCIGLK
  
Inhibitor
Name:
BDBM121053
Synonyms:
US8722896, (-)-(3R)-1-(2,3- Dimethylbenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Type:
Small organic molecule
Emp. Form.:
C28H37ClN2O3
Mol. Mass.:
485.058
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc(C)c2C)C1
Structure:
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