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Target
Egl nine homolog 1
Ligand
BDBM107711
Substrate
n/a
Meas. Tech.
Mass Spectrometry Assay
Temperature
298.15±n/a K
IC50
1200±n/a nM
Comments
extracted
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and method of use US Patent  US8722895 Publication Date 5/13/2014 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM107711
Synonyms:
US11426393, Compound Table XV.17 | US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlorophenyl)-N-(2-methylamino-2- oxoethyl)-3-hydroxypyridin-2-yl amide | US9598370, Example 00142 | USRE47437, Example 5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxypyridin-2-yl amide
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3O3
Mol. Mass.:
319.743
SMILES:
CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Structure:
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