Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM122508
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
6.5±n/a
IC50
0.34±n/a nM
Citation
 Banner, D; Haap, W; Kuhn, B; Luebbers, T; Peters, J; Schulz-Gasch, T Pyrrolidine derivatives US Patent  US8729061 Publication Date 5/20/2014 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM122508
Synonyms:
US8729061, 38
Type:
Small organic molecule
Emp. Form.:
C29H30Cl3N3O6S
Mol. Mass.:
654.989
SMILES:
CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ccc(Cl)cc1)S(=O)(=O)c1ccc(Cl)cc1Cl)C(=O)C(=O)NC1CC1 |r|
Structure:
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