Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Methionine aminopeptidase 2
Ligand
BDBM152583
Substrate
n/a
Meas. Tech.
recombinant human MetAP2 assay
pH
7.4±n/a
IC50
<50±n/a nM
Comments
extracted
Citation
Vath, JE; Zahler, R Fumagillol heterocyclic compounds and methods of making and using same US Patent US10023561 Publication Date 7/17/2018 More Info.:
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
Inhibitor
Name:
BDBM152583
Synonyms:
US10023561, Example 73 | US9682965, 73
Type:
Small organic molecule
Emp. Form.:
C27H45N3O7
Mol. Mass.:
523.6621
SMILES:
[#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#7]-[#6](=O)-[#8]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Structure:
