Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM61942
Substrate
n/a
Meas. Tech.
EMSA
pH
7.5±n/a
Temperature
296.15±n/a K
IC50
5.6e+3± 2.4e+3 nM
Comments
extracted
Citation
 Mukherjee, S; Weiner, WS; Schroeder, CE; Simpson, DS; Hanson, AM; Sweeney, NL; Marvin, RK; Ndjomou, J; Kolli, R; Isailovic, D; Schoenen, FJ; Frick, DN Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication ACS Chem Biol 9:2393-2403 (2014) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM61942
Synonyms:
2-(3-keto-1,2-benzothiazol-2-yl)-N-(o-tolyl)acetamide | 2-(3-keto-1,2-benzothiazol-2-yl)-N-(o-tolyl)acetamide (6) | 2-(3-keto-1,2-benzothiazol-2-yl)-N-(o-tolyl)acetamide (8) | KSC-4-289 | KUC104553N | N-(2-methylphenyl)-2-(3-oxidanylidene-1,2-benzothiazol-2-yl)ethanamide | N-(2-methylphenyl)-2-(3-oxo-1,2-benzothiazol-2-yl)acetamide | cid_44968084
Type:
Small organic molecule
Emp. Form.:
C16H14N2O2S
Mol. Mass.:
298.36
SMILES:
Cc1ccccc1NC(=O)Cn1sc2ccccc2c1=O
Structure:
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