Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM50220832
Substrate
n/a
Meas. Tech.
EMSA
pH
7.5±n/a
Temperature
296.15±n/a K
IC50
5.30e+5±n/a nM
Comments
extracted
Citation
 Mukherjee, S; Weiner, WS; Schroeder, CE; Simpson, DS; Hanson, AM; Sweeney, NL; Marvin, RK; Ndjomou, J; Kolli, R; Isailovic, D; Schoenen, FJ; Frick, DN Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication ACS Chem Biol 9:2393-2403 (2014) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM50220832
Synonyms:
CHEMBL8211 | N-ethylmaleimide
Type:
Small organic molecule
Emp. Form.:
C6H7NO2
Mol. Mass.:
125.1253
SMILES:
CCN1C(=O)C=CC1=O |c:5|
Structure:
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