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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM283871
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
pH
7.2±n/a
Temperature
298.15±n/a K
IC50
3.80±n/a nM
Comments
extracted
Citation
 Bhide, RS; Duncia, JV; Hynes, J; Nair, SK; Pitts, WJ; Kumar, SR; Gardner, DS; Murugesan, N; Paidi, VR; Santella, JB; Sistla, R; Wu, H Heteroaryl substituted pyridyl compounds useful as kinase modulators US Patent  US10023562 Publication Date 7/17/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM283871
Synonyms:
US10023562, Example 63 | US10544133, Example 63 | US9657009, 63
Type:
Small organic molecule
Emp. Form.:
C21H27FN6O2
Mol. Mass.:
414.4765
SMILES:
CC(C)Nc1cc(Nc2ccc(C#N)c(C)n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O |r|
Structure:
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