Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM283939
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
pH
7.2±n/a
Temperature
298.15±n/a K
IC50
10.6±n/a nM
Comments
extracted
Citation
 Bhide, RSDuncia, JVHynes, JNair, SKPitts, WJKumar, SRGardner, DSMurugesan, NPaidi, VRSantella, JBSistla, RWu, H Heteroaryl substituted pyridyl compounds useful as kinase modulators US Patent  US10023562 Publication Date 7/17/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM283939
Synonyms:
US10023562, Example 131 | US10544133, Example 131 | US9657009, 131
Type:
Small organic molecule
Emp. Form.:
C18H26FN7O2
Mol. Mass.:
391.4431
SMILES:
CC(C)Nc1cc(Nc2ccnc(N)n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O |r|
Structure:
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