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Target
Glucagon receptor
Ligand
BDBM123584
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
24.2±n/a nM
Citation
 Chakravarty, D; Kreutter, K; Powell, M; Shook, B; Song, F; Xu, G; Yang, S; Zhang, R; Zhao, B Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists US Patent  US8748624 Publication Date 6/10/2014 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM123584
Synonyms:
US8748624, 77
Type:
Small organic molecule
Emp. Form.:
C30H24Cl2F3N3O3
Mol. Mass.:
602.431
SMILES:
Cc1cc(Cl)ccc1-c1ccc(NCc2cc(Cl)c(cc2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1
Structure:
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