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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM123822
Substrate
n/a
Meas. Tech.
Human MAO inhibitory test
pH
7.4±0
Temperature
310.15±0 K
Ki
6.55e+3± 2.3e+3 nM
Citation
 Rane, RA; Napahde, S; Bangalore, PK; Sahu, NU; Shah, N; Kulkarni, YA; Barve, K; Lokare, L; Karpoormath, R Synthesis and evaluation of novel marine bromopyrrole alkaloid-based derivatives as potential antidepressant agents. Chem Biol Drug Des 84:593-602 (2014) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM123822
Synonyms:
4,5-dibromo-N'-(4-methoxybenzylidene)-1Hpyrrole-2-carbohydrazide (4i)
Type:
Small organic molecule
Emp. Form.:
C13H11Br2N3O2
Mol. Mass.:
401.053
SMILES:
COc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1 |w:7.7|
Structure:
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