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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM123827
Substrate
n/a
Meas. Tech.
Human MAO inhibitory test
pH
7.4±0
Temperature
310.15±0 K
Ki
1.33e+4± 1.1e+3 nM
Citation
 Rane, RA; Napahde, S; Bangalore, PK; Sahu, NU; Shah, N; Kulkarni, YA; Barve, K; Lokare, L; Karpoormath, R Synthesis and evaluation of novel marine bromopyrrole alkaloid-based derivatives as potential antidepressant agents. Chem Biol Drug Des 84:593-602 (2014) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM123827
Synonyms:
4,5-dibromo-N'-(4-hydroxybenzylidene)-1-methyl-1H-pyrrole-2-carbohydrazide (5d)
Type:
Small organic molecule
Emp. Form.:
C13H11Br2N3O2
Mol. Mass.:
401.053
SMILES:
Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccc(O)cc1 |w:11.11|
Structure:
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