Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase-like protein
Ligand
BDBM50299867
Substrate
n/a
Meas. Tech.
Fluorometric Assay
pH
8±n/a
Ki
41±n/a nM
IC50
230±n/a nM
Comments
extracted
Citation
 Buchholz, M; Heiser, U; Hamann, A Inhibitors of glutaminyl cyclase US Patent  US8772508 Publication Date 7/8/2014 
Target
Name:
Glutaminyl-peptide cyclotransferase-like protein
Synonyms:
Glutaminyl Cyclase | Glutaminyl-peptide cyclotransferase-like protein (QC) | QPCTL | QPCTL_HUMAN
Type:
Protein
Mol. Mass.:
42941.16
Organism:
Homo sapiens (Human)
Description:
Q9NXS2
Residue:
382
Sequence:
MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
  
Inhibitor
Name:
BDBM50299867
Synonyms:
CHEMBL565907 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)naphthalen-1-amine | US8772508, 10
Type:
Small organic molecule
Emp. Form.:
C19H21N5O2
Mol. Mass.:
351.4023
SMILES:
Cc1cncn1CCCN=C(C[N+]([O-])=O)Nc1cccc2ccccc12 |w:9.9|
Structure:
Search PDB for entries with ligand similarity: