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Target
Disintegrin and metalloproteinase domain-containing protein 33
Ligand
BDBM125919
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.4±n/a
IC50
181±n/a nM
Comments
extracted
Citation
 Clary, L; Chambon, S; Chantalat, L; Mauvais, P; Roye, O; Schuppli, M Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics US Patent  US8772478 Publication Date 7/8/2014 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 33
Synonyms:
ADA33_HUMAN | ADAM33 | C20orf153 | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)
Type:
PROTEIN
Mol. Mass.:
87748.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_492649
Residue:
813
Sequence:
MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
  
Inhibitor
Name:
BDBM125919
Synonyms:
US8772478, 3
Type:
Small organic molecule
Emp. Form.:
C21H26FN3O5S
Mol. Mass.:
451.512
SMILES:
ONC(=O)[C@H](CNS(=O)(=O)c1ccc(OCc2ccc(F)cc2)cc1)N1CCCCC1
Structure:
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