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Target
Disintegrin and metalloproteinase domain-containing protein 33
Ligand
BDBM125922
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.4±n/a
IC50
147±n/a nM
Comments
extracted
Citation
 Clary, L; Chambon, S; Chantalat, L; Mauvais, P; Roye, O; Schuppli, M Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics US Patent  US8772478 Publication Date 7/8/2014 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 33
Synonyms:
ADA33_HUMAN | ADAM33 | C20orf153 | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)
Type:
PROTEIN
Mol. Mass.:
87748.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_492649
Residue:
813
Sequence:
MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
  
Inhibitor
Name:
BDBM125922
Synonyms:
US8772478, 7
Type:
Small organic molecule
Emp. Form.:
C20H25N3O6S
Mol. Mass.:
435.494
SMILES:
ONC(=O)[C@H](CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1)N1CCOCC1
Structure:
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