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Target
Cyclin-T1
Ligand
BDBM126480
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.002±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126480
Synonyms:
US8778951, 290
Type:
Small organic molecule
Emp. Form.:
C25H32Cl2F3N5O2
Mol. Mass.:
562.455
SMILES:
O[C@@H](CN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1Cl)C(F)(F)F |r,wU:7.10,wD:4.3,1.0,(7.07,2.45,;5.73,1.68,;4.4,2.45,;3.07,1.68,;1.73,2.45,;1.73,3.99,;.4,4.76,;-.93,3.99,;-.93,2.45,;.4,1.68,;-2.27,4.76,;-3.6,3.99,;-3.6,2.45,;-4.94,1.68,;-6.27,2.45,;-7.6,1.68,;-6.27,3.99,;-4.94,4.76,;-4.94,.14,;-3.6,-.63,;-3.6,-2.17,;-2.27,-2.94,;-.93,-2.17,;.4,-2.94,;.4,-4.48,;1.73,-5.25,;3.07,-4.48,;3.07,-2.94,;1.73,-2.17,;-4.94,-2.94,;-6.27,-2.17,;-6.27,-.63,;-7.6,.14,;5.73,.14,;7.07,-.63,;4.4,-.63,;4.96,-1.2,)|
Structure:
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