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Target
Cyclin-T1
Ligand
BDBM126501
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.001±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126501
Synonyms:
US8778951, 311
Type:
Small organic molecule
Emp. Form.:
C23H32ClN5O
Mol. Mass.:
429.986
SMILES:
CC1(CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)CCOCC1 |r,wU:14.14,wD:17.18,(2.67,-1.15,;2.67,-2.69,;1.33,-1.93,;,-2.69,;-1.33,-1.93,;-2.67,-2.69,;-4,-1.93,;-4,-.38,;-2.67,.38,;-1.33,-.38,;-2.67,1.93,;-1.33,2.69,;-1.33,4.23,;,5,;1.33,4.23,;2.67,5,;4,4.23,;4,2.69,;5.33,1.93,;2.67,1.93,;1.33,2.69,;-2.67,5,;-4,4.23,;-4,2.69,;-5.33,1.93,;2.67,-4.23,;4,-5,;5.33,-4.23,;5.33,-2.69,;4,-1.92,)|
Structure:
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