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Target
Cyclin-T1
Ligand
BDBM126524
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.00027±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126524
Synonyms:
US8778951, 335
Type:
Small organic molecule
Emp. Form.:
C27H34ClFN6O3
Mol. Mass.:
545.049
SMILES:
CC1(N[C@H]2CC[C@@H](CC2)Nc2cc(c(Cl)cn2)-c2ccc(F)c(NCC3(CCOCC3)C#N)n2)OCCO1 |r,wU:6.9,wD:3.2,(4.82,1.15,;4.82,2.69,;3.48,1.93,;2.15,2.69,;2.15,4.23,;.82,5,;-.52,4.23,;-.52,2.69,;.82,1.93,;-1.85,5,;-3.19,4.23,;-3.19,2.69,;-4.52,1.93,;-5.85,2.69,;-7.19,1.93,;-5.85,4.23,;-4.52,5,;-4.52,.38,;-5.85,-.38,;-5.85,-1.93,;-4.52,-2.69,;-4.52,-4.23,;-3.19,-1.93,;-1.85,-2.69,;-.52,-1.93,;.82,-2.69,;.82,-4.23,;2.15,-5,;3.48,-4.23,;3.48,-2.69,;2.15,-1.92,;.82,-1.15,;.82,.38,;-3.19,-.38,;6.28,2.22,;7.19,3.47,;6.28,4.71,;4.82,4.23,)|
Structure:
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