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Target
Egl nine homolog 1
Ligand
BDBM102343
Substrate
n/a
Meas. Tech.
Activity Assay
pH
7.5±n/a
IC50
17000±n/a nM
Comments
extracted
Citation
 Shalwitz, R; Gardner, JH Methods for increasing the stabilization of hypoxia inducible factor-1 alpha US Patent  US8778412 Publication Date 7/15/2014 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM102343
Synonyms:
US10562854, No. B9 | US8536181, B9 | US9278930, B9
Type:
Small organic molecule
Emp. Form.:
C24H27N3O2
Mol. Mass.:
389.4901
SMILES:
Oc1c(CN2CCN(Cc3ccccc3)CC2)ccn(Cc2ccccc2)c1=O
Structure:
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