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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM143113
Substrate
n/a
Meas. Tech.
FAAH Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
17±n/a nM
Comments
extracted
Citation
 Kharul, R; Bhuniya, D; Mookhtiar, KA; Singh, U; Hazare, A; Patil, S; Datrange, L; Thakkar, M Amide compounds, compositions and applications thereof US Patent  US9682953 Publication Date 6/20/2017 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM143113
Synonyms:
US9682953, 1.A-1
Type:
Small organic molecule
Emp. Form.:
C24H21F3N4O2
Mol. Mass.:
454.4443
SMILES:
FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)C(=O)Nc3cccnn3)c2)nc1 |(-12.22,-6.75,;-10.89,-5.98,;-10.89,-4.44,;-10.89,-7.52,;-9.56,-6.75,;-8.22,-5.98,;-6.89,-6.75,;-6.89,-8.29,;-5.56,-9.06,;-4.22,-8.29,;-4.22,-6.75,;-2.89,-5.98,;-1.56,-6.75,;-1.56,-8.29,;-.22,-9.06,;1.11,-8.29,;2.45,-9.06,;3.78,-8.29,;3.78,-6.75,;2.45,-5.98,;1.11,-6.75,;5.11,-5.98,;5.11,-4.44,;6.45,-6.75,;7.78,-5.98,;7.78,-4.44,;9.11,-3.67,;10.45,-4.44,;10.45,-5.98,;9.11,-6.75,;-2.89,-9.06,;-8.22,-9.06,;-9.56,-8.29,)|
Structure:
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