Reaction Details Report a problem with these data
Target
Nicotinate-nucleotide adenylyltransferase
Ligand
BDBM81359
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
18000±n/a nM
Comments
extracted
Citation
Mackerell, Jr., A; Zhang, H; Osterman, A; Kolhatkar, R Targeting NAD biosynthesis in bacterial pathogens US Patent US8785499 Publication Date 7/22/2014
More Info.:
Target
Name:
Nicotinate-nucleotide adenylyltransferase
Synonyms:
Deamido-NAD(+) pyrophosphorylase | NADD_ECOLI | Nicotinate mononucleotide adenylyltransferase (NadD) | Nicotinate-nucleotide adenylyltransferase (NadD) | nadD | ybeN
Type:
Enzyme
Mol. Mass.:
24523.61
Organism:
Escherichia coli
Description:
P0A752
Residue:
213
Sequence:
MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHMLELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEYETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNISATIIRERLQNGESCEDLLPEPVLTYINQQGLYR