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TargetMatrix metallopeptidase 13 (MMP13)
LigandBDBM126803
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 88±n/a nM
Citation Abeywardane, AFarmer, BFarrow, NAGao, DAHeim-Riether, ASmith Keenan, LLMugge, IATaylor, SJXiong, ZYu, YZhang, Q Heteroaryl substituted indole compounds useful as MMP-13 inhibitors US Patent US8785489 Publication Date 7/22/2014
More Info.:Get all data from this article,  Assay Method
 
Matrix metallopeptidase 13 (MMP13)
Name:Matrix metallopeptidase 13 (MMP13)
Synonyms:n/a
Type:Protein
Mol. Mass.:54166.75
Organism:Mus musculus (Mouse)
Description:Q3U9V5
Residue:472
Sequence:
MHSAILATFFLLSWTPCWSLPLPYGDDDDDDLSEEDLVFAEHYLKSYYHPATLAGILKKS
TVTSTVDRLREMQSFFGLEVTGKLDDPTLDIMRKPRCGVPDVGEYNVFPRTLKWSQTNLT
YRIVNYTPDMSHSEVEKAFRKAFKVWSDVTPLNFTRIYDGTADIMISFGTKEHGDFYPFD
GPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFIVAAHELGHSLGLDHSKDPGAL
MFPIYTYTGKSHFMLPDDDVQGIQFLYGPGDEDPNPKHPKTPEKCDPALSLDAITSLRGE
TMIFKDRFFWRLHPQQVEAELFLTKSFWPELPNHVDAAYEHPSRDLMFIFRGRKFWALNG
YDILEGYPRKISDLGFPKEVKRLSAAVHFENTGKTLFFSENHVWSYDDVNQTMDKDYPRL
IEEEFPGIGNKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPTNSILWC
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  Blast E-value cutoff:
BDBM126803
NameBDBM126803
Synonyms:US8785489, 4-{[({4-[1-(4-fluoro-3-methylbenzyl)-1H-pyrazol-4-yl]-5-methyl-1H-imidazol-2-yl}carbonyl)amino]methyl}benzoic acid
TypeSmall organic molecule
Emp. Form.C24H22FN5O3
Mol. Mass.447.4616
SMILESCc1[nH]c(nc1-c1cnn(Cc2ccc(F)c(C)c2)c1)C(=O)NCc1ccc(cc1)C(O)=O
Structure
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n/a