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Target
Mitogen-activated protein kinase 1
Ligand
BDBM127601
Substrate
n/a
Meas. Tech.
Cell-Free Kinase Assays
pH
7.5±n/a
IC50
2±n/a nM
Comments
extracted
Citation
 Gerlach, M; Seipelt, I; Blumenstein, L; Mueller, G; Guenther, E; Schuster, T; Teifel, M Pyridopyrazines as highly selective ras-Raf-Mek-Erk signal transduction pathway inhibitors US Patent  US8791118 Publication Date 7/29/2014 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM127601
Synonyms:
US8791118, 164
Type:
Small organic molecule
Emp. Form.:
C23H25N7O
Mol. Mass.:
415.4909
SMILES:
CC(CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(C)c1
Structure:
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