Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50361016
Substrate
n/a
Meas. Tech.
Competition Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
13.8±n/a nM
Comments
extracted
Citation
 Black, LA; Gfesser, GA; Cowart, MD 4-substituted-2-amino-pyrimidine derivatives US Patent  US8796297 Publication Date 8/5/2014 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50361016
Synonyms:
CHEMBL501882 | US8796297, 13
Type:
Small organic molecule
Emp. Form.:
C9H15N5
Mol. Mass.:
193.2489
SMILES:
CN1CCN(CC1)c1ccnc(N)n1
Structure:
Search PDB for entries with ligand similarity: