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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM38573
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
14741±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM38573
Synonyms:
9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one | 9,10-dimethoxy-2-(2-pyridylmethylamino)-6,7-dihydropyrimid[6,1-a]isoquinolin-4-one | 9,10-dimethoxy-2-(pyridin-2-ylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one | MLS000041608 | SMR000046352 | cid_665278
Type:
Small organic molecule
Emp. Form.:
C20H20N4O3
Mol. Mass.:
364.3978
SMILES:
COc1cc2CCn3c(cc(NCc4ccccn4)nc3=O)-c2cc1OC
Structure:
Search PDB for entries with ligand similarity: