Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128209
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
115518±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128209
Synonyms:
5-methyl-N'-[(5-methyl-2-furyl)methylene]-3-thiophenecarbohydrazide | 5-methyl-N-[(E)-(5-methyl-2-furanyl)methylideneamino]-3-thiophenecarboxamide | 5-methyl-N-[(E)-(5-methyl-2-furyl)methyleneamino]thiophene-3-carboxamide | 5-methyl-N-[(E)-(5-methylfuran-2-yl)methylideneamino]thiophene-3-carboxamide | MLS000547835 | SMR000115006 | cid_9563602
Type:
Small organic molecule
Emp. Form.:
C12H12N2O2S
Mol. Mass.:
248.301
SMILES:
Cc1ccc(\C=N\NC(=O)c2csc(C)c2)o1
Structure:
Search PDB for entries with ligand similarity: