Target
Transthyretin
Ligand
BDBM128211
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
61830±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128211
Synonyms:
7-[(4-hydroxyphenyl)-[(6-methyl-2-pyridinyl)amino]methyl]-2-methyl-8-quinolinol | 7-[(4-hydroxyphenyl)-[(6-methyl-2-pyridyl)amino]methyl]-2-methyl-quinolin-8-ol | 7-[(4-hydroxyphenyl)-[(6-methylpyridin-2-yl)amino]methyl]-2-methyl-quinolin-8-ol | 7-[(4-hydroxyphenyl)-[(6-methylpyridin-2-yl)amino]methyl]-2-methylquinolin-8-ol | 7-{(4-hydroxyphenyl)[(6-methyl-2-pyridinyl)amino]methyl}-2-methyl-8-quinolinol | MLS000530643 | SMR000135621 | cid_2895747
Type:
Small organic molecule
Emp. Form.:
C23H21N3O2
Mol. Mass.:
371.4317
SMILES:
Cc1cccc(NC(c2ccc(O)cc2)c2ccc3ccc(C)nc3c2O)n1
Structure:
Search PDB for entries with ligand similarity: