Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128219
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128219
Synonyms:
MLS000588879 | SMR000212528 | [3-(1-methyl-3-indolyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-phenylmethanone | [3-(1-methylindol-3-yl)-5-phenyl-3,4-dihydropyrazol-2-yl]-phenyl-methanone | [3-(1-methylindol-3-yl)-5-phenyl-3,4-dihydropyrazol-2-yl]-phenylmethanone | [5-(1-Methyl-1H-indol-3-yl)-3-phenyl-4,5-dihydro-pyrazol-1-yl]-phenyl-methanone | [5-(1-methylindol-3-yl)-3-phenyl-2-pyrazolin-1-yl]-phenyl-methanone | cid_3814317
Type:
Small organic molecule
Emp. Form.:
C25H21N3O
Mol. Mass.:
379.4537
SMILES:
Cn1cc(C2CC(=NN2C(=O)c2ccccc2)c2ccccc2)c2ccccc12 |c:6|
Structure:
Search PDB for entries with ligand similarity: