Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128214
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128214
Synonyms:
3-(5-methyl-2-furanyl)-N,5-diphenyl-3,4-dihydropyrazole-2-carbothioamide | 3-(5-methylfuran-2-yl)-N,5-diphenyl-3,4-dihydropyrazole-2-carbothioamide | 5-(5-methyl-2-furyl)-N,3-diphenyl-2-pyrazoline-1-carbothioamide | 5-(5-methyl-2-furyl)-N,3-diphenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | MLS000325293 | SMR000161361 | cid_11841141
Type:
Small organic molecule
Emp. Form.:
C21H19N3OS
Mol. Mass.:
361.46
SMILES:
Cc1ccc(o1)C1CC(=NN1C(=S)Nc1ccccc1)c1ccccc1 |c:9|
Structure:
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