Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128218
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128218
Synonyms:
1-Chloro-6-methoxy-9H-2,4,9-triaza-fluorene | 4-chloranyl-8-methoxy-5H-pyrimido[5,4-b]indole | 4-chloro-8-methoxy-5H-pyrimid[5,4-b]indole | 4-chloro-8-methoxy-5H-pyrimido[5,4-b]indole | MLS000559714 | SMR000174930 | cid_5399944
Type:
Small organic molecule
Emp. Form.:
C11H8ClN3O
Mol. Mass.:
233.654
SMILES:
COc1ccc2[nH]c3c(Cl)ncnc3c2c1
Structure:
Search PDB for entries with ligand similarity: