Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128225
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128225
Synonyms:
2-(4-Chloro-3-fluoro-phenylamino)-7-hydroxy-4H-thiazolo[4,5-b]pyridin-5-one | 2-(4-chloro-3-fluoro-anilino)-7-hydroxy-4H-thiazolo[4,5-b]pyridin-5-one | 2-(4-chloro-3-fluoroanilino)-7-hydroxy-4H-[1,3]thiazolo[4,5-b]pyridin-5-one | 2-(4-chloro-3-fluoroanilino)-7-hydroxy-4H-thiazolo[4,5-b]pyridin-5-one | 2-[(4-chloranyl-3-fluoranyl-phenyl)amino]-7-oxidanyl-4H-[1,3]thiazolo[4,5-b]pyridin-5-one | MLS000332377 | SMR000221708 | cid_54677165
Type:
Small organic molecule
Emp. Form.:
C12H7ClFN3O2S
Mol. Mass.:
311.719
SMILES:
Oc1cc(=O)[nH]c2nc(Nc3ccc(Cl)c(F)c3)sc12
Structure:
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