Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128228
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128228
Synonyms:
(E)-1-(2,5-dichlorophenyl)-3-[4-(difluoromethylsulfanyl)anilino]-2-pyridin-1-ium-1-yl-3-sulfanylideneprop-1-en-1-olate | (E)-1-(2,5-dichlorophenyl)-3-[4-(difluoromethylthio)anilino]-2-(1-pyridin-1-iumyl)-3-sulfanylidene-1-propen-1-olate | (E)-1-(2,5-dichlorophenyl)-3-[4-(difluoromethylthio)anilino]-2-pyridin-1-ium-1-yl-3-thioxo-prop-1-en-1-olate | (E)-1-[2,5-bis(chloranyl)phenyl]-3-[[4-[bis(fluoranyl)methylsulfanyl]phenyl]amino]-2-pyridin-1-ium-1-yl-3-sulfanylidene-prop-1-en-1-olate | MLS001006684 | SMR000349628 | cid_16195927
Type:
Small organic molecule
Emp. Form.:
C21H14Cl2F2N2OS2
Mol. Mass.:
483.381
SMILES:
[O-]\C(=C(/C(=S)Nc1ccc(SC(F)F)cc1)[n+]1ccccc1)c1cc(Cl)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: