Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128231
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128231
Synonyms:
Acridin-9-yl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine | MLS000768230 | N-[2-(3,4-dimethoxyphenyl)ethyl]-9-acridinamine;hydrochloride | N-[2-(3,4-dimethoxyphenyl)ethyl]acridin-9-amine;hydrochloride | SMR000431551 | acridin-9-yl(homoveratryl)amine;hydrochloride | cid_16682491
Type:
Small organic molecule
Emp. Form.:
C23H23ClN2O2
Mol. Mass.:
394.894
SMILES:
Cl.COc1ccc(CCNc2c3ccccc3nc3ccccc23)cc1OC
Structure:
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