Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128233
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128233
Synonyms:
(5Z)-5-[(E)-3-(1,3-benzodioxol-5-yl)-1-hydroxy-prop-2-enylidene]-1-butyl-barbituric acid | (5Z)-5-[(E)-3-(1,3-benzodioxol-5-yl)-1-hydroxyprop-2-enylidene]-1-butyl-1,3-diazinane-2,4,6-trione | (5Z)-5-[(E)-3-(1,3-benzodioxol-5-yl)-1-oxidanyl-prop-2-enylidene]-1-butyl-1,3-diazinane-2,4,6-trione | 5-((E)-3-Benzo[1,3]dioxol-5-yl-acryloyl)-3-butyl-6-hydroxy-1H-pyrimidine-2,4-dione | MLS000763033 | SMR000439468 | cid_54677751
Type:
Small organic molecule
Emp. Form.:
C18H18N2O6
Mol. Mass.:
358.3453
SMILES:
CCCCN1C(=O)NC(=O)\C(=C(\O)/C=C/c2ccc3OCOc3c2)C1=O
Structure:
Search PDB for entries with ligand similarity: