Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3
Ligand
BDBM128457
Substrate
n/a
Meas. Tech.
In Vitro Kinase Inhibition Assay
pH
8±n/a
Temperature
298.15±n/a K
IC50
0.82±n/a nM
Comments
extracted
Citation
 Berdini, V; Carr, MG; Congreve, MS; Frederickson, M; Griffiths-Jones, CM; Hamlett, CC; Madin, A; Murray, CW; Benning, RK; Saxty, G; Vickerstaffe, E; Williams, BJ; Woodhead, AJ; Woodhead, SJ; Freyne, EJ; Govaerts, TC; Angibaud, PR Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases US Patent  US8796244 Publication Date 8/5/2014 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM128457
Synonyms:
US8796244, 36
Type:
Small organic molecule
Emp. Form.:
C27H29F3N8O
Mol. Mass.:
538.5674
SMILES:
CN(C)C1CCN(CC1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Structure:
Search PDB for entries with ligand similarity: