Reaction Details Report a problem with these data
Target
Protein UL24 homolog
Ligand
BDBM130377
Substrate
n/a
Meas. Tech.
Nuclear Magnetic Resonance (NMR) Assay
pH
8±n/a
IC50
3.7e+3± 7e+2 nM
Comments
extracted
Citation
 Gable, JE; Lee, GM; Jaishankar, P; Hearn, BR; Waddling, CA; Renslo, AR; Craik, CS Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry 53:4648-60 (2014) [PubMed]  Article 
Target
Name:
Protein UL24 homolog
Synonyms:
Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr) | ORF20 | UL24_HHV8P
Type:
Protein
Mol. Mass.:
28447.41
Organism:
Human herpesvirus 8
Description:
Q2HRB2
Residue:
257
Sequence:
MVRPTEAEVKKSLSRLPAARKRAGNRAHLATYRRLLKYSTLPDLWRFLSSRPQNPPLGHHRLFFEVTLGHRIADCVILVSGGHQPVCYVVELKTCLSHQLIPTNTVRTSQRAQGLCQLSDSIHYIAHSAPPGTEAWTITPLLIFKNQKTLKTVYSESPGAFPTPVHTTEGKLCAFLTARENADIRKVLSKVPKKPKMDRGGKILGPTPGKRAVYSQAHHGRNKKGRPWTAQPTRAKSRTKDKGTPAFPRAGPACSGP
  
Inhibitor
Name:
BDBM130377
Synonyms:
N-[2-Benzyl-4-(methylsulfonylcarbamoyl)phenyl]-6-(cyclohexylmethyl)pyridine-2- carboxamide (3)
Type:
Small organic molecule
Emp. Form.:
C28H31N3O4S
Mol. Mass.:
505.628
SMILES:
CS(=O)(=O)NC(=O)c1ccc(NC(=O)c2cccc(CC3CCCCC3)n2)c(Cc2ccccc2)c1
Structure:
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