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TargetKetohexokinase
LigandBDBM130619
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
Temperature298.15±n/a K
IC50 600±n/a nM
Commentsextracted
Citation Zhang, XAbad, MCGibbs, ACKuo, GKuo, LCSong, FSui, Z Indazole compounds useful as ketohexokinase inhibitors US Patent US8822447 Publication Date 9/2/2014
More Info.:Get all data from this article,  Assay Method
 
Ketohexokinase
Name:Ketohexokinase
Synonyms:Hepatic fructokinase | Ketohexokinase (KHK)
Type:Enzyme
Mol. Mass.:32521.64
Organism:Homo sapiens (Human)
Description:P50053
Residue:298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
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  Blast E-value cutoff:
BDBM130619
NameBDBM130619
Synonyms:US8822447, 99 | US9771375, Example 99
TypeSmall organic molecule
Emp. Form.C24H25N5O
Mol. Mass.399.4882
SMILESCc1nn(-c2ccccc2)c2nc(cc(CO)c12)-c1ccc(cc1)N1CCNCC1
Structure
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