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TargetPhosphodiesterase 9A
LigandBDBM131014
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 2±n/a nM
Citation Okada, MSato, SKawade, KGotanda, KShinbo, ANakano, YKobayashi, H Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors US Patent US8829000 Publication Date 9/9/2014
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase 9A
Name:Phosphodiesterase 9A
Synonyms:High affinity cGMP-specific 3'',5''-cyclic phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A)
Type:Protein
Mol. Mass.:68488.40
Organism:Homo sapiens (human)
Description:O76083
Residue:593
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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  Blast E-value cutoff:
BDBM131014
NameBDBM131014
Synonyms:US8829000, 187
TypeSmall organic molecule
Emp. Form.C14H10F3N3O3
Mol. Mass.325.2427
SMILESOC(=O)CCc1ncc2n1c1ccc(cc1[nH]c2=O)C(F)(F)F
Structure
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