Reaction Details Report a problem with these data
Target
G-protein coupled receptor 6
Ligand
BDBM191030
Substrate
n/a
Meas. Tech.
Inhibition of cAMP Activity of GPR6 In Vitro A.1 Assay
IC50
113500±n/a nM
Citation
Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent US10077266 Publication Date 9/18/2018
More Info.:
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
Inhibitor
Name:
BDBM191030
Synonyms:
US10077266, Example 142 | US9181249, 142 | US9708313, 142
Type:
Small organic molecule
Emp. Form.:
C26H31F2N5O4
Mol. Mass.:
515.5522
SMILES:
CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O |r,wU:6.8,4.3,(2.67,-4.94,;1.33,-5.71,;1.33,-7.25,;,-4.94,;,-3.4,;1.09,-2.31,;,-1.22,;-1.09,-2.31,;,.32,;1.33,1.09,;2.67,.32,;4,1.09,;5.33,.32,;6.67,1.09,;6.67,2.63,;5.33,3.4,;4,2.63,;2.67,3.4,;1.33,2.63,;,3.4,;,4.94,;-1.33,5.71,;-2.67,4.94,;-2.67,3.4,;-1.33,2.63,;-4,5.71,;-5.33,4.94,;-5.33,3.4,;-6.67,2.63,;-8,3.4,;-9.34,2.63,;-8,4.94,;-6.67,5.71,;-6.67,7.25,;8,.32,;9.34,1.09,;8,-1.22,)|