Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 2
Ligand
BDBM131882
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence Assay
IC50
2026±n/a nM
Citation
 Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent  US8835444 Publication Date 9/16/2014 
Target
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R 2 | CRF2 | CRF2R | CRFR2_HUMAN | CRH-R 2 | CRH2R | CRHR2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 (CRF-2) | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | Corticotropin-releasing hormone receptor 2
Type:
Enzyme
Mol. Mass.:
47694.70
Organism:
Homo sapiens (Human)
Description:
Q13324
Residue:
411
Sequence:
MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
  
Inhibitor
Name:
BDBM131882
Synonyms:
US8835444, 5.27
Type:
Small organic molecule
Emp. Form.:
C21H25ClF3N3O
Mol. Mass.:
427.891
SMILES:
CCc1cc(C)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)n1 |r,wU:8.7,wD:11.14,(9.91,1.86,;8.58,2.63,;7.25,1.86,;6.77,.39,;5.23,.39,;4.46,-.94,;4.76,1.86,;3.42,2.63,;2.09,1.86,;2.09,.32,;.75,-.45,;-.58,.32,;-.58,1.86,;.75,2.63,;-1.91,-.45,;-3.25,.32,;-3.25,1.86,;-4.58,-.45,;-5.91,.32,;-7.25,-.45,;-7.25,-1.99,;-5.91,-2.76,;-4.58,-1.99,;-3.25,-2.76,;-8.58,.32,;-8.58,1.86,;-9.91,-.45,;-9.91,1.09,;6,2.76,)|
Structure:
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