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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50352748
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
IC50
88±n/a nM
Comments
extracted
Citation
 Lee, J; Seo, HJ; Kang, SY; Park, E; Kim, MJ; Lee, SH; Kim, JY; Kim, J; Jung, ME; Kim, HJ; Kim, M; Han, HK; Ahn, KW; Lee, MW; Lee, K; Pae, AN; Park, W Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same US Patent  US8835436 Publication Date 9/16/2014 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50352748
Synonyms:
CHEMBL1822904 | US8835436, Example 10
Type:
Small organic molecule
Emp. Form.:
C26H31Cl2N5O2
Mol. Mass.:
516.463
SMILES:
COc1ccc(cc1)-n1c(C)nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c1C
Structure:
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