Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50352755
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
IC50
37.4±n/a nM
Comments
extracted
Citation
 Lee, J; Seo, HJ; Kang, SY; Park, E; Kim, MJ; Lee, SH; Kim, JY; Kim, J; Jung, ME; Kim, HJ; Kim, M; Han, HK; Ahn, KW; Lee, MW; Lee, K; Pae, AN; Park, W Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same US Patent  US8835436 Publication Date 9/16/2014 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50352755
Synonyms:
CHEMBL1823068 | US8835436, Example 144
Type:
Small organic molecule
Emp. Form.:
C27H34ClN5O2
Mol. Mass.:
496.044
SMILES:
COc1ccccc1-n1c(C)nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2C)c1C |(-6,-2.67,;-6,-4.21,;-7.34,-4.97,;-8.67,-4.2,;-10.01,-4.97,;-10.01,-6.52,;-8.67,-7.28,;-7.34,-6.51,;-6.01,-7.29,;-5.54,-8.75,;-6.31,-10.08,;-4,-8.75,;-3.52,-7.29,;-2.18,-6.52,;-2.18,-4.98,;-.85,-7.29,;.48,-6.52,;1.82,-7.29,;3.15,-6.52,;4.48,-7.28,;5.8,-6.5,;7.13,-7.27,;7.14,-8.81,;5.81,-9.58,;4.47,-8.82,;8.47,-9.57,;9.81,-8.79,;11.14,-9.56,;11.15,-11.1,;9.81,-11.87,;9.81,-13.41,;8.48,-11.11,;7.14,-11.88,;-4.77,-6.38,;-4.77,-4.84,)|
Structure:
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