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Target
Cyclin-dependent kinase 4
Ligand
BDBM132263
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
0.91±n/a nM
Citation
 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors US Patent  US8841312 Publication Date 9/23/2014 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM132263
Synonyms:
US8841312, 5
Type:
Small organic molecule
Emp. Form.:
C24H28N8
Mol. Mass.:
428.5327
SMILES:
Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1
Structure:
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