Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM134272
Substrate
n/a
Meas. Tech.
Inhibitory Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
20±n/a nM
Comments
extracted
Citation
 Muto, T; Tanaka, T; Futamura, J; Imajo, S; Sugawara, H Seven-membered ring compound and pharmaceutical use therefor US Patent  US8846660 Publication Date 9/30/2014 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM134272
Synonyms:
US8846660, 58
Type:
Small organic molecule
Emp. Form.:
C25H28ClN9O5
Mol. Mass.:
570
SMILES:
CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)C(=O)Nc1nnn[nH]1 |r|
Structure:
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