Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM134597
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
8±n/a nM
Citation
 Adams, CM; Darsigny, V; Flyer, AN; Gelin, CF; Hurley, TB; Ji, N; Karki, RG; Kawanami, T; Meredith, E; Rao, C; Serrano-Wu, MH; Solovay, CF Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators US Patent  US8846656 Publication Date 9/30/2014 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM134597
Synonyms:
US8846656, 69-M
Type:
Small organic molecule
Emp. Form.:
C29H33ClN8O
Mol. Mass.:
545.078
SMILES:
Cc1n[nH]c2ccc(C)c(-c3nc4CCN(Cc4c(n3)N3CC[C@H]4OC[C@H]4C3)c3c(Cl)c(nn3C)C3CC3)c12 |r|
Structure:
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