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Target
Uridine phosphorylase 1
Ligand
BDBM135808
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.3±n/a
Temperature
310.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
 Garland, WA; Frenzel, BD; Karg, T Methotrexate adjuvants to reduce toxicity and methods for using the same US Patent  US8853227 Publication Date 10/7/2014 
Target
Name:
Uridine phosphorylase 1
Synonyms:
UP | UPP1 | UPP1_HUMAN | UPase 1 | UrdPase 1 | Uridine phosphorylase (UPase)
Type:
Enzyme
Mol. Mass.:
33939.54
Organism:
Homo sapiens (Human)
Description:
Q16831
Residue:
310
Sequence:
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
  
Inhibitor
Name:
BDBM135808
Synonyms:
US8853227, TK- 000011 | USRE48253, Designation TK-000011
Type:
Small organic molecule
Emp. Form.:
C10H11N5O4
Mol. Mass.:
265.2254
SMILES:
Cc1cn2[C@@H]3O[C@H](CN=[N+]=[N-])[C@@H](O)[C@@H]3Oc2nc1=O |r|
Structure:
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