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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM136256
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
125±n/a nM
Comments
extracted
Citation
 Heckel, A; Himmelsbach, F; Kley, J; Lehmann-Lintz, T; Redemann, N; Sauer, A; Thomas, L; Wiedenmayer, D; Black, P; Blackaby, W; Linney, I; Austen, M; Danilewicz, J; Schneider, M; Schreiter, K Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions US Patent  US8853193 Publication Date 10/7/2014 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM136256
Synonyms:
US8853193, 47
Type:
Small organic molecule
Emp. Form.:
C19H16F2N4O3S
Mol. Mass.:
418.417
SMILES:
COC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C
Structure:
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