Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50293078
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
298.15±n/a K
Kd
12000±n/a nM
Comments
extracted
Citation
 Clinch, K; Evans, GB; Furneaux, RH; Gulab, SA; Kelly, PM; Schramm, VL; Tyler, PC; Woolhouse, AD Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases US Patent  US8853224 Publication Date 10/7/2014 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM50293078
Synonyms:
7-({[(2S,3R)-2,3,4-Trihydroxybutyl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL502217
Type:
Small organic molecule
Emp. Form.:
C11H16N4O4
Mol. Mass.:
268.2691
SMILES:
OC[C@@H](O)[C@@H](O)CNCc1c[nH]c2c1nc[nH]c2=O |r|
Structure:
Search PDB for entries with ligand similarity: