Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM136312
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
298.15±n/a K
Kd
1100±n/a nM
Comments
extracted
Citation
 Clinch, K; Evans, GB; Furneaux, RH; Gulab, SA; Kelly, PM; Schramm, VL; Tyler, PC; Woolhouse, AD Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases US Patent  US8853224 Publication Date 10/7/2014 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM136312
Synonyms:
US8853224, 29
Type:
Small organic molecule
Emp. Form.:
C20H26N4O3S
Mol. Mass.:
402.51
SMILES:
CSCC(CN(Cc1c[nH]c2c1nc[nH]c2=O)Cc1ccccc1)[C@H](O)CO
Structure:
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