Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM136342
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Ki
0.85±n/a nM
Comments
extracted
Citation
 Andersson, J; Gyback, H; Johansson, A; Linde, CE; Malmstrom, J; Nordvall, G; Weigelt, T; Terp, G 2-carboxamide-7-piperazinyl-benzofuran derivatives US Patent  US8859534 Publication Date 10/14/2014 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-hydroxytryptamine receptor 1A (5HT1A)
Type:
Protein
Mol. Mass.:
46351.20
Organism:
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Description:
G3I1B6
Residue:
422
Sequence:
MDIFSLGQGNNTTSSQEPFGTGGNVTGISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGASTSLSTSSAPPPKKSLNGQPGNGDWRRSAENRAVGAPCANGAVRQGDDEATLEVIEVHRVGNSKDHLPLPSESGATSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM136342
Synonyms:
US8859534, 28
Type:
Small organic molecule
Emp. Form.:
C28H30N4O3
Mol. Mass.:
470.5628
SMILES:
COc1ccc(CNC(=O)c2cc3cccc(N4CCN(CCc5ccccn5)CC4)c3o2)cc1
Structure:
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