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Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Ligand
BDBM137926
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Temperature
303.15±n/a K
IC50
3330±n/a nM
Comments
extracted
Citation
 Motomura, T; Nagamori, H; Suzawa, K; Ito, H; Morita, T; Kobayashi, S; Shinkai, H Fluorene compound and pharmaceutical use thereof US Patent  US8871934 Publication Date 10/28/2014 
Target
Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Synonyms:
PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2)
Type:
Enzyme
Mol. Mass.:
46153.78
Organism:
Homo sapiens (Human)
Description:
Q15119
Residue:
407
Sequence:
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
  
Inhibitor
Name:
BDBM137926
Synonyms:
US8871934, 519 | US8871934, 520
Type:
Small organic molecule
Emp. Form.:
C15H10ClF3O
Mol. Mass.:
298.688
SMILES:
Cc1cc2c(-c3ccccc3C2(O)C(F)(F)F)c(Cl)c1
Structure:
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